More than half the the companies started in Eden failed to survive in business up to the end of 2019.
The Federation of Small Businesses says firms were “already up against it” before the COVID-19 pandemic – but they are now reporting record falls in revenue with many posed to cut staff numbers.
Office for National Statistics data shows 200 businesses in Eden were set up in 2014 – but after three years 135 were still active, and by 2019 just 95 remained.
That equates to a five-year survival rate of 48 per cent.
In the North West, Burnley had the lowest rate, 33 per cent, while South Lakeland had the highest at 52 per cent.
Across the UK, the five-year survival rate to 2019 was 43 per cent.
Survival rates for businesses in clothes manufacturing, food services and food services such as restaurants were among the lowest nationally.
In the FSB’s Small Business Index report, Mike Cherry, national chairman, said small firms were already struggling with political uncertainty and a surge in operating costs before the COVID-19 pandemic.
He said Government support, such as the Eat Out to Help Out scheme, had led to a summer bounce, but that many were now struggling.
He added: “Firms still report a record drop in revenues, while the number planning to let staff go is at an all-time high
“Exporters– still without any significant clarity around what the future holds for trade with Europe – say international sales have plummeted.”
Last year, 185 new businesses were launched in Eden.
At last count there were 2,470 active companies in the area.
The ONS figures also reveal one-year survival rates for companies set up in 2018.
In Eden 150 businesses were still active one year on from launch, a survival rate of 91 per cent which is slightly higher than the UK rate of 89 per cent.
Due to coronavirus restrictions imposed from March, many industries in the UK have been hit by enforced closures or lower takings.
The Government has provided a range of support for businesses over the pandemic including a Bounce Back Loan Scheme, the opportunity to defer VAT payments and business rates holidays.
The Coronavirus Job Retention Scheme has also been extended until March.
A spokesman said: “We are committed to making the UK the best place in the world to start and grow a business.
“That is why we have invested more than £623 million in start-up loans for 75,000 new businesses since 2012 and created a competitive tax environment that rewards entrepreneurship.
“We are also looking to refresh our Industrial Strategy to stimulate economic growth to create jobs and new business opportunities for decades to come.
“But we also understand the pressure businesses are currently under, which is why we have acted to support them through the pandemic with a £280 billion support package, which is among the most generous in the world.”